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Understanding the Context

Programmable gene integration in human cells has the potential to enable mutation-agnostic treatments for loss-of-function genetic diseases and facilitate many applications in the life sciences. CRISPR. Huanglongbing (HLB) is a devastating citrus disease. In this work, we report an HLB resistance regulatory circuit in Citrus composed of an E3 ubiquitin ligase, PUB21, and its substrate,.

Key Insights

Authoritative, up-to-the-minute news and in-depth features on research advances and science policy, from award-winning science journalists. Explore cutting-edge research and insights in the scientific world with Science AAAS Research. Toxic metal pollution is ubiquitous in soils, yet its worldwide distribution is unknown. We analyzed a global database of soil pollution by arsenic, cadmium, cobalt, chromium, copper, nickel,. Systemic drug administration often causes off-target effects, limiting the efficacy of advanced therapies.

Final Thoughts

Targeted drug delivery approaches increase local drug concentrations at the. The gut microbiota is known to be associated with a variety of human metabolic diseases, including metabolic dysfunctionassociated steatohepatitis (MASH). Fungi are increasingly.